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Serum or Plasma Creatinine Concentration (Standard Method)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of creatinine, a waste product from muscle metabolism, in your blood or plasma. It helps assess how well your kidneys are filtering waste from your blood.

Quick summary

["A key indicator of kidney function and overall kidney health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
26254-3
Short code
XR tomo IAC-L
Synonyms
XR tomo IAC-L
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
98
Ref high
107
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
xr-tomography
CPT
82435
SNOMED
110743000
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Your Kidneys Matter

Creatinine is a natural byproduct of muscle breakdown and is normally filtered out of your blood by your kidneys. When kidney function declines, creatinine levels can rise, indicating impaired filtering. This test helps doctors monitor kidney health, especially in people with conditions like diabetes, high blood pressure, or those taking medications that may affect kidney function.

What to Expect Before the Test

No special preparation is needed for this test. You may have blood drawn from a vein in your arm, or if testing urine, you’ll collect a sample in a container. If you’re on a low-protein diet or have recently exercised heavily, let your healthcare provider know—these can temporarily affect creatinine levels.

Common Causes of Abnormal Results

High creatinine levels may suggest kidney problems, dehydration, or conditions like heart failure or muscle disorders. Low levels could indicate overhydration, liver disease, or certain medications. Always discuss any concerns with your doctor.

How This Test Helps Your Doctor

Your doctor uses creatinine levels to track kidney function over time, diagnose kidney disease, or evaluate how well treatments are working. It’s often used alongside other tests, like blood urea nitrogen (BUN), to get a full picture of kidney health.

Reference range

Adult: 98-107 mmol/LN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Creatinine levels can help detect early kidney damage, monitor progression of kidney disease, and guide decisions about medications or therapies. It’s also useful in diagnosing conditions like acute kidney injury or chronic kidney disease.

Short name

Creatinine Level

Frequently asked questions

Will I feel any pain or discomfort during the blood draw?
You may feel a slight pinch or sting when the needle goes in, but it usually doesn’t last long. Some people experience a small bruise or swelling at the site. If you’re nervous, let your healthcare provider know—they can use a smaller needle or apply ice afterward.
Can diet affect my creatinine test results?
Yes, eating a high-protein diet or exercising intensely before the test could temporarily raise creatinine levels. Avoiding these factors for a day or two before testing can give more accurate results. Always follow your doctor’s specific instructions.
What if my creatinine level is outside the normal range?
If your results are abnormal, your doctor will review them with you and may recommend further testing or adjustments to your treatment plan. High levels often mean kidney issues, while low levels may signal other health concerns—don’t interpret results alone; always talk to your healthcare provider.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy