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Monoclonal Protein Profile (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the levels of abnormal proteins, called monoclonal proteins, that may appear in your blood or urine. These proteins can be linked to conditions like multiple myeloma or other blood disorders.

Quick summary

["Abnormal proteins in your blood may signal serious health conditions that need medical attention."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
37606-1
Short code
XR tomo Nasal bones
Synonyms
XR tomo Nasal bones
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
xr-tomography
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like unexplained fatigue, frequent infections, bone pain, or if tests suggest an unusual protein buildup in your blood. It’s also used to monitor conditions like multiple myeloma or other monoclonal gammopathies.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm to draw blood. If you’re being tested for urine monoclonal proteins, you’ll collect a urine sample in a clean container.

What the Test Results Mean

Results show the presence and type of monoclonal proteins. High levels or unusual patterns may indicate conditions like multiple myeloma, lymphoma, or other blood disorders. Your provider will discuss these findings with you.

Common Conditions Linked to This Test

Abnormal findings can help diagnose or monitor conditions such as multiple myeloma (a cancer of plasma cells), Waldenström macroglobulinemia (a type of lymphoma), or benign monoclonal gammopathies (non-cancerous protein abnormalities).

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test plays a key role in diagnosing and managing blood disorders by identifying abnormal proteins that may not be detected by routine blood tests. Early detection can lead to timely treatment and better outcomes. Your provider will use these results to guide further testing or treatment plans.

Short name

Monoclonal Protein Screen

Frequently asked questions

What does a positive test result mean?
A positive result means your blood or urine contains abnormal proteins. This doesn’t always mean you have a serious condition, but it warrants further evaluation by your healthcare provider to determine the cause and next steps.
How often should I get this test?
Your provider will determine how often you need this test based on your health history, symptoms, and treatment plan. Some people may need it yearly or more frequently if they have a condition like multiple myeloma.
Can lifestyle changes affect my test results?
While certain conditions (like dehydration) might temporarily affect protein levels, lifestyle changes like diet or exercise usually don’t directly influence this test. Always follow your provider’s advice for test timing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy