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Total Protein (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum, which includes albumin and other proteins like globulins.

Quick summary

["Your blood protein levels help assess overall health and detect conditions like malnutrition or kidney disease."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
25071-2
Short code
XR tomo Unsp region
Synonyms
XR tomo Unsp region
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
xr-tomography
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why It’s Done

Healthcare providers may order a total protein test to check for signs of kidney disease, liver problems, malnutrition, or certain immune system disorders. It can also help diagnose conditions like multiple myeloma or chronic infections.

What to Expect

A small blood sample is drawn from your arm. You may feel a slight pinch, but it usually doesn’t cause discomfort. The test is quick and requires no special preparation.

Normal vs. Abnormal Results

While reference ranges vary by lab, lower than expected levels might suggest malnutrition or protein-losing conditions, while higher levels could indicate liver disease or dehydration.

Common Conditions Linked to Results

Low protein levels may signal kidney disease, severe infections, or digestive disorders that prevent proper protein absorption. High levels could point to liver disease, multiple myeloma, or dehydration.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

What causes low total protein levels?
Conditions like severe malnutrition, kidney disease, or certain digestive disorders (e.g., celiac disease) can lead to lower protein levels. Chronic infections or liver problems may also contribute.
What causes high total protein levels?
High protein levels can result from conditions like multiple myeloma, severe dehydration, or liver disease. Rarely, certain medications or genetic factors may play a role.
Do I need to prepare for this test?
No special preparation is needed, but avoid heavy meals 1–2 hours before your blood draw to ensure accurate results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy