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Total Protein in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum, which includes proteins like albumin and globulins that help with immunity, fluid balance, and other vital functions.

Quick summary

["Your blood protein levels can help doctors assess overall health, detect kidney issues, or identify nutritional deficiencies."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
37932-1
Short code
XR tomo Wrist
Synonyms
XR tomo Wrist
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
xr-tomography
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does Total Protein Measure?

Total protein is a broad measure of all protein substances in your blood. It reflects the balance between albumin (which helps maintain fluid balance in your tissues) and globulins (which support immune function and transport substances like hormones). Abnormal levels may indicate conditions like malnutrition, liver disease, or kidney problems.

Why Might Your Doctor Order This Test?

Doctors may check total protein levels if you have symptoms like swelling, unexplained weight loss, fatigue, or if they suspect conditions like chronic kidney disease, liver disease, or certain infections. It’s also sometimes used as part of a general health screening.

What to Expect Before the Test

No special preparation is needed for this test. You may have a small needle inserted into your arm or vein to draw a blood sample. If you’re on blood thinners, let your doctor know before the test to avoid unusual bleeding.

What to Expect During the Test

The blood sample is taken quickly and usually causes only minor discomfort. You may feel a slight pinch or sting, but it’s over in seconds. The blood is then sent to a lab for analysis.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

How Total Protein Levels Can Affect Your Health

Short name

Total Protein

Frequently asked questions

How often should I get this test?
The frequency depends on your health status and why the test was ordered. Your doctor will determine how often you need it based on your symptoms, medical history, and other tests.
What are the normal ranges for total protein?
There isn’t a single standard range for all labs, as it can vary slightly by testing facility. Typically, adult reference ranges are around 6.4 to 8.3 grams per deciliter (g/dL). Your actual results will be compared to your specific lab’s reference values.
Can diet affect my total protein test results?
Yes, your diet can influence protein levels. Eating a balanced diet with adequate protein from foods like lean meats, dairy, beans, and whole grains can help maintain healthy levels. Avoiding extreme diets or malnutrition may also impact your results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy