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Serum or Plasma Vitamin D Binding Protein (DBP) Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of vitamin D binding protein in your blood, which helps transport vitamin D and other hormones. It may be used to assess how well your body is processing certain substances related to vitamin D metabolism.

Quick summary

["Understanding your vitamin D binding protein levels can help evaluate hormone function and metabolism."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
98283-5
Short code
XR UGI Views
Synonyms
XR UGI Views
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
xr
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if they suspect issues with how your body processes vitamin D or related hormones. It could be part of a broader evaluation for conditions affecting protein metabolism, hormone balance, or kidney function.

What to Expect Before the Test

No special preparation is typically needed. You may have a blood sample drawn from a vein in your arm. If you’re taking medications that affect protein levels, let your provider know.

What the Results Mean

Results provide insight into the concentration of vitamin D binding protein in your blood. While specific ranges vary by lab, abnormal levels might indicate problems with protein synthesis, hormone transport, or kidney function.

Common Conditions Monitored

This test may be part of investigations for conditions like nephrotic syndrome, liver disease, or disorders affecting protein synthesis, though it’s less commonly used than direct vitamin D tests.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical significance: While vitamin D binding protein is crucial for transporting vitamin D and other hormones, its primary clinical role is less direct than measuring vitamin D itself. Abnormal levels may suggest underlying metabolic or kidney issues but are often secondary to other tests.

Short name

Vitamin D Binding Protein Level

Frequently asked questions

What does a high or low vitamin D binding protein level mean?
High levels might indicate conditions like nephrotic syndrome or liver disease, where protein loss or synthesis is affected. Low levels could suggest protein malnutrition or other metabolic disturbances, but results should be interpreted alongside clinical context.
Does this test help diagnose vitamin D deficiency?
No, this test measures the protein carrier, not vitamin D levels directly. For vitamin D deficiency, tests like 25-hydroxy vitamin D are typically used instead.
How often should I get this test?
Your provider will determine frequency based on your health needs. Routine screening for vitamin D binding protein is uncommon unless you have specific medical concerns.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy