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Blood Group Antibody Screening (Serum) by Immunohematology

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies in your blood that may react against certain red blood cell antigens, helping identify potential blood compatibility issues or immune responses.

Quick summary

Helps determine if you have antibodies that could affect blood transfusions or pregnancy outcomes.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
50962-0
Short code
XXX blood group IgG Titr SerPl
Synonyms
XXX blood group IgG Titr SerPl
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
8
Ref high
61
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82977
SNOMED
3110003
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order this test if you’re preparing for a blood transfusion, expecting a baby, or experiencing symptoms like anemia, jaundice, or unexplained bleeding. It also helps screen donors for compatibility before transfusions.

What to Expect During the Test

A small blood sample is drawn from a vein in your arm. The serum (liquid part of blood without clots) is tested for specific antibodies using a method called immunohematology, which detects reactions with known red blood cell antigens.

How the Results Are Interpreted

Results are qualitative (yes/no) and indicate whether antibodies are present. Positive findings mean further testing (confirmation) may be needed to identify which specific antibodies are present.

Preparation for the Test

No special preparation is needed. You can eat, drink, or take medications as usual on the day of the test. Avoid alcohol or strenuous activity before the draw if advised by your doctor.

Reference range

Adult males: 8-61 U/L; Adult females: 5-36 U/LN/A

Specimen: serum

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Positive results can signal potential risks for blood transfusions, pregnancy complications (such as hemolytic disease of the fetus and newborn), or autoimmune conditions. It’s critical for safe blood donation and patient care in emergency or elective surgeries.

Short name

IgG Antibody Screening (Blood)

Frequently asked questions

What does a positive result mean?
A positive result means your blood contains antibodies that may react with certain red blood cell antigens. This could affect blood compatibility during transfusions or pregnancy, so further testing is needed to determine the exact antibody profile.
How long does it take to get results?
Results are typically available within 24 to 48 hours, depending on the lab’s processing time. Your doctor will discuss the findings with you during a follow-up visit.
Can I fast before this test?
No fasting is required for this test. However, always follow your doctor’s specific instructions if they recommend any preparations.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy