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Serum Vitamin E (Alpha-Tocopherol) Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of vitamin E, a fat-soluble antioxidant found in your blood, which helps protect cells from damage.

Quick summary

["Vitamin E supports heart health, immune function, and skin protection."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
61545-0
Short code
Years vit E PhenX
Synonyms
Years vit E PhenX
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
phenx
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may order this test if you have symptoms like muscle weakness, nerve problems, or if you have conditions like chronic liver disease, malabsorption issues, or certain genetic disorders that affect vitamin E levels. It may also be checked in people with high-risk factors for vitamin E deficiency, such as those on long-term fat-soluble vitamin supplements or with certain medications that interfere with absorption.

What to Expect Before the Test

No special preparation is usually needed. You may be asked to fast for 8–12 hours before the test if it involves drawing blood from your arm. If you’re taking vitamin E supplements, your doctor may advise stopping them for a few days before the test.

How the Test Is Performed

A blood sample is taken from a vein in your arm by a healthcare professional. The blood is then sent to a lab for analysis using a method called **electrophoresis** to measure vitamin E levels.

What the Results Mean

Results are compared to a reference range, but exact values can vary by lab. Low levels may indicate deficiency, while high levels could suggest excess intake or certain medical conditions. Your doctor will interpret the results in the context of your overall health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Low vitamin E levels can lead to oxidative stress, affecting nerve function, vision, and immune response. Deficiency is rare but may occur in people with malabsorption disorders (e.g., celiac disease, Crohn’s), liver disease, or those on certain medications. High levels may require investigation into underlying causes, such as genetic disorders or excessive supplementation.

Short name

Vitamin E Level

Frequently asked questions

What causes vitamin E deficiency?
Vitamin E deficiency can result from poor diet (e.g., very low-fat foods), malabsorption issues (like celiac disease or pancreatic insufficiency), chronic liver disease, or certain medications that interfere with absorption. Rarely, genetic disorders may also lead to low levels.
What symptoms might I experience if my vitamin E level is low?
Symptoms of low vitamin E may include muscle weakness, nerve pain, vision problems, or balance issues. Some people may not notice symptoms until deficiency is severe. If you experience these or other unexplained symptoms, talk to your doctor.
How is vitamin E deficiency treated?
Treatment typically involves dietary changes to increase vitamin E-rich foods (e.g., nuts, seeds, leafy greens) or oral supplements if absorption is impaired. Your doctor may recommend specific supplements or monitor levels closely to avoid excess.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy