Skip to content

Total Protein in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein found in your blood serum, which includes albumin and globulins. Proteins are essential for maintaining fluid balance, supporting immune function, and transporting nutrients.

Quick summary

["Your blood protein levels help ensure proper health and function of your body’s systems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
39544-2
Short code
Yellow Hornet IgE/IgE total %
Synonyms
Yellow Hornet IgE/IgE total %
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like swelling (edema), frequent infections, unexplained weight changes, or signs of kidney disease. It can also be part of routine health checks or monitoring for conditions like liver disease or malnutrition.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if it’s part of a liver function panel. Bring any medications you’re currently taking to your appointment.

How the Test Is Performed

A healthcare professional will draw blood from a vein in your arm using a small needle. You may feel a slight pinch, but the procedure is quick and typically painless. The blood sample is then sent to a lab for analysis.

What the Results Mean

Low protein levels may indicate conditions like kidney disease, liver problems, or malnutrition, while high levels could suggest dehydration, inflammation, or certain cancers. Your results will be interpreted by your provider in the context of your overall health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Total Protein

Frequently asked questions

How often do I need this test?
The frequency depends on your health status. Routine blood panels may include this test every 1–3 years, but your provider will determine if more frequent testing is needed based on your symptoms or risk factors.
Can I eat or drink before this test?
If fasting is required (e.g., for a liver panel), avoid food and liquids except water for 8–12 hours beforehand. If no fasting is needed, you can eat and drink normally.
What if my protein levels are out of range?
If your results are abnormal, your provider may recommend further testing or treatments to address the underlying cause, such as dietary changes, medication adjustments, or monitoring for conditions like kidney disease.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy