Serum or plasma concentration of total bile acids

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like jaundice (yellowing of skin/eyes), unexplained fatigue, abdominal pain, or if they suspect liver disease, gallbladder issues, or bile duct blockage. It can also help diagnose conditions like primary biliary cholangitis or evaluate liver function before surgery or treatment.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if it’s part of a liver function panel. Avoid alcohol and certain medications (like NSAIDs) for 24 hours beforehand. Bring a list of medications to your doctor.

How the Test Works

A blood sample is drawn from a vein in your arm. The sample is sent to a lab, where bile acids are measured using a sensitive chemical test (likely immunoassay or enzymatic method). Results are compared to a reference range to assess your health.

What the Results Mean

Elevated levels may indicate liver disease, bile duct obstruction, or gallbladder problems. Lower-than-normal levels could suggest liver dysfunction or certain metabolic disorders. Your doctor will interpret results in the context of your symptoms and other tests.