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Serum or plasma concentration of total bilirubin

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of bilirubin in your blood. Bilirubin is a yellow pigment produced when red blood cells break down, and it helps your liver process waste products.

Quick summary

["Bilirubin helps identify liver function and bile flow issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
6590-4
Short code
YFV Ab Titr Ser LA
Synonyms
YFV Ab Titr Ser LA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
la
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Doctors may order a total bilirubin test to check for liver disease, bile duct blockages, or other conditions that affect how your liver processes bilirubin. It can also help diagnose conditions like hepatitis, gallstones, or hemolytic anemia.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if it involves a blood draw. Avoid alcohol and certain medications that could affect results for 24 hours before testing.

A healthcare provider will draw blood from a vein in your arm using a needle. The blood sample is sent to a lab for analysis.

The test measures the total bilirubin level in your serum or plasma, which includes both direct and indirect (unconjugated) bilirubin.

Possible Results and Their Meaning

Higher than normal levels may suggest liver problems, bile duct blockages, or red blood cell breakdown. Lower levels may indicate liver disease or other conditions affecting bilirubin metabolism.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total bilirubin

Frequently asked questions

What causes elevated bilirubin levels?
Elevated bilirubin can result from liver disease, bile duct obstructions (e.g., gallstones), red blood cell breakdown (hemolysis), or certain medications. Jaundice (yellowing of skin/eyes) is a common symptom of high bilirubin.
How long does it take to get results?
Results are typically available within 1–2 business days, depending on your lab. Follow-up with your doctor if you have concerns about your results.
Can diet or medications affect this test?
Certain foods (e.g., carrots, spinach) or medications (e.g., antibiotics, NSAIDs) may influence bilirubin levels. Always inform your doctor about all medications or supplements you take before testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy