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IgG Immunoglobulin Subclass 1 (Serum)

Published: August 9, 2026Updated: August 17, 2026

This test measures the level of Immunoglobulin G (IgG) subclass 1, a type of antibody in your blood. IgG1 is one of the main components of the immune system that helps fight infections and diseases.

Quick summary

["IgG1 helps protect your body by identifying and neutralizing harmful substances."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
102848-9
Short code
Yogurt IgE RAST
Synonyms
Yogurt IgE RAST
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
10
Ref high
40
Critical range
— – 500 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
rast
CPT
84484
SNOMED
302774002
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

IgG1 is a subtype of Immunoglobulin G (IgG), which is the most common antibody in your blood. This test specifically looks at the concentration of IgG1, which plays a key role in immune defense. Levels can vary depending on your immune response, health status, and certain medical conditions.

Why Might You Need This Test?

Your healthcare provider may order this test if you have symptoms or conditions that could involve immune system issues, such as recurrent infections, autoimmune diseases, or certain allergies. It may also be used to monitor treatment responses in conditions like chronic infections or immune-related disorders.

Common Reasons for Testing

Tests like this are often part of broader evaluations for immune function. They can help diagnose or monitor conditions where IgG1 levels might be abnormal, such as in immune deficiencies, certain cancers, or after receiving immune-modifying treatments.

What to Expect Before the Test

No special preparation is usually needed for this blood test. You may be asked to fast for a few hours before the draw, but this depends on your healthcare provider’s instructions. A healthcare professional will collect a small amount of blood from a vein in your arm.

Reference range

Adult: 10-40 U/LN/A

Specimen: serum

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IgG1 Subclass

Frequently asked questions

What Are My IgG1 Levels Telling Me?
IgG1 levels can provide insights into your immune system’s ability to produce antibodies. Low levels might suggest an immune deficiency or a condition that affects antibody production, while high levels could be seen in chronic infections, certain autoimmune diseases, or after vaccination.
How Do My IgG1 Results Compare to Others?
While reference ranges can vary by lab, IgG1 levels are typically measured in grams per liter (g/L). Your results will be compared to a standard range provided by your healthcare provider to determine if they are within normal limits or if further investigation is needed.
Can IgG1 Levels Change Over Time?
Yes, IgG1 levels can fluctuate due to various factors, including infections, vaccinations, chronic illnesses, or treatments that affect the immune system. Regular monitoring may be recommended if you have a condition that impacts antibody production or response.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy