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Prostate-Specific Antigen (PSA) Screening with Liquid Chromatography-Mass Spectrometry (LC-MS) Quantification

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of prostate-specific antigen (PSA) in your blood, a protein produced by both normal and cancerous prostate cells. PSA levels can help assess prostate health, including the risk of prostate cancer.

Quick summary

["PSA levels may indicate prostate health or potential cancer risk; results guide further medical evaluation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
101371-3
Short code
Y pestis DNA Bld Pos Ql NAA+n-prb
Synonyms
Y pestis DNA Bld Pos Ql NAA+n-prb
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
non-probe-amp-tar
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order a PSA test to monitor prostate health, especially in men at higher risk for prostate cancer. It can also be used during follow-up after treatment or for screening in certain populations. This test helps track changes over time and supports early detection efforts.

What to Expect Before the Test

No special preparation is needed, but you may be asked to avoid ejaculation for 2–3 days before testing to get an accurate result. Wear comfortable clothing and plan to stay for about 15 minutes while a blood sample is drawn.

What the Test Results Mean

PSA levels alone don’t diagnose prostate cancer—they’re part of a broader evaluation. Higher levels may signal concern, prompting additional tests like a digital rectal exam or biopsy. Your doctor will discuss results in the context of your medical history and symptoms.

Common Causes of Elevated PSA Levels

Elevated PSA can result from benign conditions like benign prostatic hyperplasia (BPH), infections, or recent prostate procedures. It may also be linked to prostate cancer, though other factors can influence results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: PSA Testing in Prostate Health

Short name

PSA Screening

Frequently asked questions

What factors might affect my PSA test results?
Several factors can influence PSA levels, including age, race, recent ejaculation, prostate inflammation, or medications. Discuss these with your healthcare provider to interpret results accurately.
How often should I get a PSA test?
The need for PSA testing depends on your age, family history, and overall health. The U.S. Preventive Services Task Force recommends against routine PSA screening for men under 55, but doctors may suggest it for higher-risk individuals or after prostate concerns arise.
Can PSA levels be misleading?
Yes, PSA levels can be misleading due to variability from benign conditions or other factors. A doctor will consider the test alongside clinical findings, imaging, and patient history to guide diagnosis and treatment.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy