Skip to content

Zap70 T-Cell Receptor Gene Mutation Status (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test checks for a specific genetic change in T-cells, which may be linked to certain blood disorders or cancers like T-cell lymphoma.

Quick summary

["Helps identify genetic mutations that could affect immune cell function or cancer risk."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
46234-1
Short code
ZAP70 Cells NFr Mar
Synonyms
ZAP70 Cells NFr Mar
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend this test if you have symptoms like persistent fatigue, unexplained weight loss, or swollen lymph nodes, or if you have a family history of blood cancers. It may also be used during diagnosis or monitoring of conditions like chronic lymphocytic leukemia (CLL) or T-cell lymphoma.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from your arm. The test analyzes a protein (Zap70) produced by certain T-cells, which can be detected in blood or other body fluids.

How the Results Are Interpreted

Results are qualitative (positive or negative) and indicate whether the mutation is present. A positive result means the mutation is detected, which may influence treatment planning or further testing.

Common Conditions Monitored

This test is primarily used in the diagnosis or monitoring of T-cell-related blood cancers, such as T-cell lymphoma or certain subtypes of leukemia. It may also help assess genetic predispositions in inherited blood disorders.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Zap70 Mutation Test

Frequently asked questions

What does a positive result mean?
A positive result suggests the presence of the Zap70 mutation in your T-cells, which may indicate a higher likelihood of certain blood cancers or help guide treatment options. This mutation can sometimes be associated with more aggressive disease progression.
How often is this test repeated?
The frequency depends on your medical condition and treatment plan. Your doctor may order follow-up tests to monitor changes in the mutation status over time, especially if you’re undergoing treatment for a blood disorder or cancer.
Can lifestyle changes affect this test?
No, this test focuses on a genetic mutation and does not respond to lifestyle factors like diet or exercise. However, your overall health and treatment adherence may influence how your condition is managed.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy