Zap70 T-Cell Receptor Gene Mutation (Qualitative) in Peripheral Blood
This test checks for a specific genetic mutation in your white blood cells, which may be linked to certain types of blood cancers, such as T-cell lymphoma.
["A mutation in the Zap70 gene could help determine if you have a rare blood disorder or cancer requiring targeted treatment."]
Key facts at a glance
- LOINC
- 53618-5
- Short code
- ZAP70 Cells Spec Ql
- Synonyms
- ZAP70 Cells Spec Ql
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your doctor may recommend this test if you have symptoms like unexplained weight loss, persistent fatigue, swollen lymph nodes, or a history of blood-related cancers. It’s also used in diagnosing or monitoring certain T-cell lymphomas or other hematologic conditions.
What to Expect Before the Test
No special preparation is needed. A blood sample will be drawn from a vein, usually in your arm. The test analyzes white blood cells for the Zap70 mutation, which is detected through genetic testing methods.
What the Results Mean
A positive result means the mutation is present in your blood cells. This finding can guide treatment decisions, such as whether you need specific therapies like immunotherapy or targeted drugs. A negative result means the mutation is not detected in this sample.
Common Reasons for Testing
Doctors use this test to diagnose or confirm conditions like T-cell lymphoma, chronic lymphocytic leukemia (CLL), or other rare blood disorders. It helps tailor treatment plans to address the specific genetic changes in your cancer.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance: The Zap70 mutation is associated with aggressive forms of T-cell lymphomas and may influence disease progression. Identifying this mutation helps doctors choose more effective treatments, such as monoclonal antibodies or other targeted therapies, to improve outcomes.
Short name
Zap70 Mutation Test
Frequently asked questions
What does a positive result mean for my treatment options?
Will this test affect my insurance coverage or out-of-pocket costs?
How long will it take to get my results?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy