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Protein Electrophoresis on Serum (Qualitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the different types of proteins in your blood, including albumin and globulins, to help identify abnormalities in protein distribution.

Quick summary

["Helps diagnose conditions like multiple myeloma, liver disease, or kidney problems by checking protein patterns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
108188-4
Short code
ZIKV RNA Smn Ql NAA+probe
Synonyms
ZIKV RNA Smn Ql NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Proteins Are Measured?

Your blood sample is separated into fractions based on protein size and charge. Common bands include albumin (fast-moving), alpha, beta, and gamma globulins (slower-moving). Abnormal bands or shifts may indicate disease.

Why Is This Test Done?

A doctor may order this test to investigate symptoms like unexplained weight loss, fatigue, swelling, or signs of organ dysfunction (e.g., liver or kidney issues). It’s also used in screening for conditions like multiple myeloma or autoimmune diseases.

Sample Preparation and Testing Process

A blood sample is drawn, and serum is separated. The sample is then run through an electric field in a gel medium, causing proteins to migrate at different speeds. Results are visually interpreted as bands or patterns.

Common Conditions This Test Helps Diagnose

Abnormal patterns may signal conditions like multiple myeloma (excess monoclonal proteins), liver disease (reduced albumin), or chronic inflammation (increased globulins). It’s not a definitive test alone but guides further evaluation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Protein electrophoresis is critical for identifying monoclonal gammopathies (e.g., plasma cell disorders), evaluating protein synthesis disorders, or monitoring treatment responses in conditions like lupus or rheumatoid arthritis. It’s often used alongside other tests for comprehensive diagnosis.

Short name

Serum Protein Electrophoresis

Frequently asked questions

What does a ‘spike’ or ‘band’ in the electrophoresis result mean?
A spike or band may indicate an abnormal protein, such as a monoclonal protein (seen in multiple myeloma) or a specific type of globulin. Your doctor will discuss the pattern with you and may recommend further testing.
How long does it take to get results from this test?
Results are typically available within 24 to 48 hours, depending on lab processing times. Follow-up with your healthcare provider is needed to interpret the results in the context of your symptoms and medical history.
Can I eat or drink anything before this test?
No special preparation is needed for this test. You can eat and drink normally, but avoid smoking or excessive alcohol before your blood draw if advised by your doctor.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy