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Zonisamide and Creatinine, Urine

Published: August 9, 2026Updated: August 16, 2026

A urine test that measures the anticonvulsant zonisamide along with creatinine, which can help account for differences in urine concentration.

Quick summary

["This test helps clinicians evaluate zonisamide exposure, medication use, and possible toxicity."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
87771-2
Short code
Zonisamide/Creat Ur Cfm
Synonyms
Zonisamide/Creat Ur Cfm
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
confirm
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures the amount of zonisamide, a medicine used to treat seizures, in a urine sample. Creatinine is measured at the same time to help evaluate how concentrated the urine is.

Why might I need this test?

A clinician may order this test to check medication use, assess zonisamide exposure, or investigate signs of too much medicine. The result may also help with dose monitoring and medication safety.

How is the test performed?

You provide a urine sample according to the laboratory's instructions. The laboratory measures zonisamide and creatinine in the sample and may compare the results or calculate a concentration-corrected value.

How do I prepare for the test?

Follow any urine collection schedule, timing, and container instructions provided by your clinician or laboratory. Record the collection date and time, and do not change or stop zonisamide unless your healthcare professional advises you to do so.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urine Zonisamide and Creatinine

Frequently asked questions

Is this the same as a zonisamide blood test?
No. This test uses a urine sample rather than blood, so the results may not directly match a blood zonisamide concentration. The laboratory's interpretation should be considered.
Why is creatinine measured with zonisamide?
Urine can vary widely in how concentrated it is. Creatinine helps the laboratory account for that variation when interpreting the zonisamide result.
Does an abnormal result mean I have a seizure disorder?
No. This test monitors medication exposure and safety; it does not diagnose or rule out a seizure disorder. Your clinician will interpret it in the context of your medical history and examination.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy