Serum or Plasma Protein Electrophoresis (Bromocresol Green)

What This Test Measures

The bromocresol green dye binds to proteins of different sizes, allowing them to separate into distinct bands on an electrophoresis gel. Each band represents a group of proteins with similar properties. The test detects variations in protein concentration across these bands, which can reveal underlying health issues.

How the Test Works

Your blood sample is drawn and processed to separate serum or plasma components. The bromocresol green dye is added, and an electric field causes the proteins to migrate toward the opposite charge. After separation, the gel is stained to visualize protein bands.

Common Uses

This test is commonly used to screen for conditions affecting protein production, such as multiple myeloma (a cancer of plasma cells), liver disease, or certain autoimmune disorders. It may also help monitor treatment progress in patients with known protein-related conditions.

When You Might Need This Test

Your healthcare provider may recommend this test if you have symptoms like unexplained weight loss, fatigue, frequent infections, or abnormal lab results. It’s also used in follow-up care for patients with known conditions affecting protein balance.