4-Aminobenzoic Acid
4-Aminobenzoic Acid (PABA) is an organic compound classified under dermatologicals that has been used in skin protection preparations. It functions primarily as a UV-absorbing agent in sunscreen formulations and topical skin products. While its use in commercial sunscreen products has diminished in favor of newer chemical filters, it remains available in certain topical preparations for photoprotection.
A topical dermatological agent primarily used for UV radiation absorption and sun protection of the skin.
Key facts at a glance
- ATC
- D02BA01
- RxNorm
- 74
- Generic
- 4-Aminobenzoic Acid
- Class
- atc-d02
- Brands
- SwineAid
- Availability
- rx
- Lactation
- unknown
- Routes
- oral, topical
- Forms
- tablet, cream
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 500mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 250mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 400mg daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
7 groupspregnancy
first trimesteravoid oral use
avoid oral 4-aminobenzoic acid during pregnancy due to limited safety data; topical use in sunscreen formulations may be considered but with caution
regular prenatal monitoring if used
Use with caution and monitor for adverse effects.
pregnancy
third trimesteravoid oral use
continue to avoid oral supplementation; topical sunscreen use is generally considered low risk
standard prenatal care
Use with caution and monitor for adverse effects.
lactation
breastfeedingavoid oral use
avoid oral supplementation while breastfeeding; topical use in sunscreen is acceptable
monitor infant for any unusual reactions
Use with caution and monitor for adverse effects.
pediatric_age
children under 12not recommended for oral supplementation in children
avoid oral formulations in pediatric patients; topical sunscreen use is permitted under supervision
monitor for skin sensitivity reactions
Use with caution and monitor for adverse effects.
geriatric
elderly over 65use with caution if oral supplementation considered
start with lower doses if oral use is deemed necessary; monitor for gastrointestinal tolerance
regular monitoring of renal and hepatic function
Use with caution and monitor for adverse effects.
renal_impairment
mild to moderateno specific adjustment for topical use; reduce oral dose if used
use topical formulations preferentially; if oral use necessary, consider dose reduction
monitor renal function periodically
Use with caution and monitor for adverse effects.
hepatic_impairment
mild to moderateuse with caution
prefer topical formulations; if oral use required, monitor liver function
periodic liver function tests
Use with caution and monitor for adverse effects.
Statistics and clinical data
IUPAC name
Chemical identification
Common abbreviation
Commonly used abbreviation
Primary applications
Common therapeutic and commercial uses
FDA status
Regulatory classification
Used for protection against ultraviolet B (UV-B) radiation, prevention of sunburn, and general skin photoprotection in topical formulations.
Absorbs UV-B radiation (280-320 nm wavelengths) and converts it into harmless thermal energy, preventing penetration of damaging rays into the skin.
May cause skin irritation or allergic reactions in sensitive individuals. Can stain clothing when used in topical formulations. Effectiveness may vary based on formulation and individual skin type. Not recommended as sole sun protection; should be used alongside other sun safety measures.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 24, 2026. · Read our editorial policy