Abaloparatide
Abaloparatide is a synthetic peptide analog of parathyroid hormone-related protein (PTHrP) used primarily for the treatment of osteoporosis in postmenopausal women at high risk for fractures. It works by mimicking the effects of PTH to stimulate new bone formation, increasing bone mineral density and reducing fracture risk.
Abaloparatide is a bone-building medication that treats osteoporosis by acting like a parathyroid hormone to stimulate new bone formation.
Key facts at a glance
- ATC
- H05AA04
- RxNorm
- 1921069
- Generic
- Abaloparatide
- Class
- atc-h05
- Brands
- Tymlos
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of osteoporosis in postmenopausal women at high risk for fractures, particularly those who have failed or are intolerant to other osteoporosis therapies.
Abaloparatide is a PTHrP(1-34) analog that acts as an agonist at the PTH1 receptor (PTH1R), activating the cAMP signaling pathway in target cells. Once-daily administration stimulates new bone formation on both trabecular and cortical bone surfaces, increasing bone mass and strength.
Administered as a daily subcutaneous injection. Use is contraindicated in patients with hypercalcemia, Paget's disease, or with unexplained elevated alkaline phosphatase. Patients should be monitored for hypercalcemia, especially when used with calcium supplements or thiazide diuretics. Treatment duration is typically limited to 24 months due to potential risk of osteosarcoma in animal studies.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy