Abiraterone / Niraparib
Abiraterone/Niraparib is a combination medication that combines an androgen synthesis inhibitor with a PARP inhibitor for the treatment of prostate cancer. This combination is specifically indicated for patients with BRCA-positive metastatic castration-resistant prostate cancer, addressing both hormone-driven growth and DNA repair mechanisms in cancer cells.
A combination therapy targeting BRCA-positive metastatic prostate cancer through dual mechanisms of androgen inhibition and PARP blockade.
Key facts at a glance
- RxNorm
- 2645240
- Generic
- Abiraterone / Niraparib
- Class
- multi-ingredient
- Brands
- Akeega
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of BRCA-positive metastatic castration-resistant prostate cancer (mCRPC) in adults who are appropriate for androgen deprivation therapy.
Abiraterone inhibits CYP17 enzyme to reduce androgen production, while Niraparib inhibits PARP enzymes involved in DNA repair, causing accumulated DNA damage in tumor cells with BRCA mutations.
Regular monitoring of liver function, blood counts, and blood pressure is required. May cause fatigue, anemia, and musculoskeletal pain. Contraindicated in pregnancy. Should be used with prednisone or prednisolone.
Official drug label
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy