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Acebutolol / Hydrochlorothiazide

Published: July 27, 2026Updated: August 25, 2026

Acebutolol/Hydrochlorothiazide is a combination medication that merges a beta-blocker with a thiazide diuretic to manage hypertension. This multi-ingredient approach helps lower blood pressure through complementary mechanisms, typically prescribed when single-agent therapy proves insufficient.

Quick summary

A combination antihypertensive medication pairing a beta-blocker with a diuretic for enhanced blood pressure control.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

RxNorm
392564
Generic
Acebutolol / Hydrochlorothiazide
Class
multi-ingredient
Brands
—
Availability
rx
Lactation
unknown
Routes
—
Forms
—
Regions
US, EU, CN, JP
Monitoring
—

This page is for informational purposes only.

Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.

Primarily used to treat hypertension (high blood pressure) in patients requiring combination therapy. May be prescribed when either component alone provides inadequate blood pressure control.

Acebutolol is a cardioselective beta-blocker that reduces heart rate and the force of heart contractions, while hydrochlorothiazide is a thiazide diuretic that helps the kidneys eliminate excess sodium and water, decreasing blood volume. Together, they lower blood pressure through complementary pathways.

May cause dizziness or fatigue; avoid alcohol and prolonged sun exposure. Monitor for electrolyte imbalances, particularly low potassium. Do not discontinue abruptly. Inform your doctor of any breathing problems, diabetes, kidney disease, or gout before starting therapy.

Official drug label

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy