Acebutolol / Mefruside
Acebutolol/Mefruside is a combination medication pairing a beta-blocker with a loop diuretic for the management of hypertension. Acebutolol works by reducing heart rate and cardiac output, while Mefruside helps eliminate excess fluid through increased urine production. This combination is typically prescribed when single-agent therapy proves insufficient for blood pressure control.
A combination antihypertensive medication used to lower blood pressure through dual action of a beta-blocker and diuretic.
Key facts at a glance
- RxNorm
- 1007003
- Generic
- Acebutolol / Mefruside
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primary use is for the treatment of essential hypertension (high blood pressure) when combination therapy is warranted. May be used when patients require both heart rate reduction and fluid removal for adequate blood pressure management.
Acebutolol blocks beta-adrenergic receptors, reducing heart rate and the force of cardiac contractions. Mefruside inhibits sodium and water reabsorption in the kidney tubules, promoting diuresis and reducing fluid volume. Together they provide complementary blood pressure-lowering effects.
Regular monitoring of blood pressure, electrolytes, and kidney function is recommended during treatment. May cause dizziness or fatigue; alcohol and concurrent medications should be discussed with a healthcare provider. Not recommended during pregnancy without careful risk-benefit assessment. Abrupt discontinuation should be avoided.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy