Acebutolol / Nifedipine
Acebutolol/Nifedipine is a combination antihypertensive medication that pairs a beta-blocker with a calcium channel blocker. This multi-ingredient approach provides complementary mechanisms for lowering blood pressure, making it useful for patients who require more aggressive blood pressure control than single-agent therapy can provide.
A combination blood pressure medication that pairs a beta-blocker (acebutolol) with a calcium channel blocker (nifedipine) for enhanced antihypertensive effect.
Key facts at a glance
- RxNorm
- 1008980
- Generic
- Acebutolol / Nifedipine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily prescribed for hypertension (high blood pressure) in patients who require combination therapy to achieve adequate blood pressure control. May be considered when single-agent therapy with either a beta-blocker or calcium channel blocker alone is insufficient.
Acebutolol is a cardioselective beta-1 blocker that reduces heart rate and cardiac output by blocking stress hormone receptors in the heart. Nifedipine is a dihydropyridine calcium channel blocker that relaxes blood vessel walls by preventing calcium from entering vascular smooth muscle cells. Together they reduce blood pressure through complementary mechanisms targeting both cardiac function and vascular resistance.
Do not discontinue abruptly as this may cause rebound hypertension or worsening angina. Common side effects may include fatigue, dizziness, headache, peripheral edema, and bradycardia. Both components can affect heart function, so inform your healthcare provider of any heart conditions, severe bradycardia, or respiratory disorders before use. Avoid grapefruit juice as it may increase nifedipine levels. Regular blood pressure and heart rate monitoring is essential during treatment.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy