Acemetacin
Acemetacin is a non-steroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation associated with rheumatic diseases and musculoskeletal conditions. It is commonly prescribed for conditions such as osteoarthritis, rheumatoid arthritis, and other inflammatory disorders.
Acemetacin is an NSAID used to reduce pain, inflammation, and fever in patients with rheumatic and musculoskeletal conditions.
Key facts at a glance
- ATC
- M01AB11
- RxNorm
- 16695
- Generic
- Acemetacin
- Class
- atc-m01
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 500mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 250mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 400mg daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
8 groupspregnancy
first trimesteravoid if possible
avoid use during pregnancy unless benefits significantly outweigh risks
regular prenatal monitoring
Use with caution and monitor for adverse effects.
pregnancy
third trimestercontraindicated
do not use in third trimester
not applicable
Use of this medication in this population requires careful consideration of risks and benefits.
lactation
breastfeedinguse with caution
avoid or discontinue breastfeeding during treatment
monitor infant for adverse effects
Use with caution and monitor for adverse effects.
geriatric
elderlyreduce dose, start with lowest effective dose
use lowest effective dose for shortest duration, monitor for GI bleeding and renal function
regular monitoring of renal function, CBC, and GI symptoms
Use with caution and monitor for adverse effects.
renal_impairment
mild to moderatereduce dose by 25-50%
use with caution, monitor renal function closely
regular renal function monitoring (creatinine, BUN)
Use with caution and monitor for adverse effects.
renal_impairment
severeavoid
contraindicated in severe renal impairment
not applicable
Use of this medication in this population requires careful consideration of risks and benefits.
hepatic_impairment
mild to moderatereduce dose, monitor liver function
use with caution, may require dose reduction
regular liver function tests (AST, ALT, bilirubin)
Use with caution and monitor for adverse effects.
pediatric_age
children adolescentsnot recommended
not approved for use in children and adolescents
not applicable
Use of this medication in this population requires careful consideration of risks and benefits.
Statistics and clinical data
Commonly prescribed since
General prescribing information
Drug class
Drug class information
Common uses
Common therapeutic uses
Mechanism of action
Pharmacological mechanism
Acemetacin is used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and other inflammatory conditions causing pain and swelling of joints and soft tissues.
Acemetacin works by inhibiting cyclooxygenase (COX) enzymes, which reduces the production of prostaglandins—chemicals involved in inflammation, pain, and fever.
Like other NSAIDs, Acemetacin may cause gastrointestinal side effects, kidney problems, or cardiovascular risks. It should be used with caution in patients with a history of ulcers, heart disease, or kidney impairment. Use during pregnancy should be avoided, particularly in the third trimester.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 24, 2026. · Read our editorial policy