Acemetacin / Chlorzoxazone
Acemetacin/Chlorzoxazone is a combination medication pairing an NSAID with a muscle relaxant to address both pain and muscle spasm simultaneously. The NSAID component provides anti-inflammatory and analgesic effects, while the muscle relaxant helps reduce skeletal muscle tension. This combination is particularly useful for musculoskeletal conditions involving both inflammation and associated muscle tightness.
A combination NSAID and muscle relaxant used for painful musculoskeletal conditions involving muscle spasm and inflammation.
Key facts at a glance
- RxNorm
- 816659
- Generic
- Acemetacin / Chlorzoxazone
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of acute musculoskeletal pain associated with muscle spasms, such as neck and back pain, sprains, strains, and other soft tissue injuries. May also be used for tension headaches and fibromyositis.
Acemetacin works by inhibiting cyclooxygenase enzymes to reduce inflammation, pain, and fever. Chlorzoxazone acts on the spinal cord and brain stem to reduce muscle spasm and associated pain through central nervous system depression.
May cause drowsiness and dizziness; avoid operating machinery or driving until effects are known. Should not be used in patients with active peptic ulcers, severe liver or kidney impairment, or in late pregnancy. Alcohol should be avoided during treatment. May interact with other CNS depressants and anticoagulants.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy