Acetaminophen / Antipyrine / Caffeine
This medication is a combination analgesic used primarily for the relief of tension headaches and mild to moderate pain. It combines acetaminophen with antipyrine for enhanced pain and fever relief, while caffeine helps constrict dilated blood vessels in the head and boosts the effectiveness of the pain relievers. The combination is typically prescribed when simple analgesics alone prove insufficient for headache management.
A triple-action headache remedy combining two pain relievers with caffeine for enhanced relief of tension headaches.
Key facts at a glance
- RxNorm
- 1009027
- Generic
- Acetaminophen / Antipyrine / Caffeine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily used for tension headaches and mild to moderate pain such as headaches, muscle aches, and general pain conditions. May also be used for migraine relief in some formulations.
Acetaminophen and antipyrine work by inhibiting pain signals in the nervous system and reducing fever. Caffeine acts as a mild stimulant and vasoconstrictor, helping to narrow dilated blood vessels in the brain that contribute to headaches while enhancing the analgesic effects of the other ingredients.
Should not be combined with alcohol as this increases risk of liver damage. Avoid use in patients with liver disease, kidney problems, or those who are pregnant or breastfeeding without medical consultation. Caffeine content may cause insomnia or jitters in sensitive individuals. Do not exceed recommended daily limits of acetaminophen to prevent liver toxicity.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy