Acetaminophen / Aspirin / Caffeine
This multi-ingredient medication combines acetaminophen, aspirin, and caffeine to provide relief for pain and headaches. The three ingredients work together to target pain through different mechanisms. It is commonly used for tension headaches, migraines, and minor aches.
An over-the-counter pain reliever combining acetaminophen, aspirin, and caffeine for headache and minor pain relief.
Key facts at a glance
- RxNorm
- 466584
- Generic
- Acetaminophen / Aspirin / Caffeine
- Class
- multi-ingredient
- Brands
- Pamprin Max Formula, Arthriten Inflammatory Pain, Backaid IPF, Excedrin, Vanquish, Exaprin Plus, Anacin Advanced Headache Formula
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used to treat tension headaches, migraines, menstrual cramps, muscle aches, toothaches, and fever. Often marketed specifically for headache relief.
Acetaminophen and aspirin provide analgesic and fever-reducing effects through different pathways, while caffeine acts as a mild stimulant that may enhance pain relief and improve blood flow.
Should not be used by individuals allergic to any ingredient, those with bleeding disorders, or those taking blood thinners. Avoid alcohol while taking this medication. Not recommended for children or teenagers recovering from viral infections due to Reye's syndrome risk associated with aspirin. Consult a healthcare provider if pain persists beyond 10 days or fever beyond 3 days.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy