Acetaminophen / Aspirin / Caffeine / Calcium Gluconate
This combination medication contains four active ingredients that work together to provide relief from pain and fever. Acetaminophen and aspirin are analgesics that reduce pain and fever, caffeine acts as a mild stimulant that may enhance pain relief, and calcium gluconate provides supplemental calcium. This multi-ingredient formulation is typically used for treating headaches, including tension headaches and migraines, as well as general pain and fever associated with various conditions.
A combination analgesic with caffeine enhancement used for headaches and general pain relief.
Key facts at a glance
- RxNorm
- 689551
- Generic
- Acetaminophen / Aspirin / Caffeine / Calcium Gluconate
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Relief of mild to moderate pain including tension headaches, migraine headaches, toothache, muscle aches, menstrual cramps, and fever reduction.
Acetaminophen and aspirin work by reducing prostaglandin production and altering pain perception. Caffeine may enhance the effectiveness of analgesics and promote vasoconstriction. Calcium gluconate provides supplemental calcium to address potential calcium deficiency.
Not suitable for individuals allergic to aspirin or acetaminophen. Should be used with caution in patients with bleeding disorders, liver disease, or kidney problems. Avoid alcohol while taking this medication. Not recommended for children or teenagers recovering from viral infections due to Reye's syndrome risk associated with aspirin. Consult a healthcare provider before use if pregnant, nursing, or taking other medications.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy