Acetaminophen / Aspirin / Caffeine / Hydrocodone
This combination medication contains four active ingredients that work together to relieve moderate to severe pain. Hydrocodone is an opioid analgesic, while acetaminophen and aspirin provide non-opioid pain relief, and caffeine may enhance the analgesic effect. This medication is typically prescribed when other pain treatments have not provided adequate relief.
A combination pain medication containing an opioid (hydrocodone) with acetaminophen, aspirin, and caffeine used for moderate to severe pain.
Key facts at a glance
- RxNorm
- 689553
- Generic
- Acetaminophen / Aspirin / Caffeine / Hydrocodone
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of moderate to severe pain requiring an opioid analgesic, typically when other non-opioid pain relievers have been insufficient. This may include pain from injuries, dental procedures, or post-surgical recovery.
Hydrocodone binds to opioid receptors in the brain and spinal cord to alter pain perception. Acetaminophen reduces pain and fever through central nervous system mechanisms. Aspirin inhibits cyclooxygenase (COX) enzymes to reduce inflammation and pain. Caffeine acts as a mild stimulant and may help constrict blood vessels to enhance pain relief.
This medication carries risk of dependence, addiction, and respiratory depression, particularly with prolonged use or misuse. Combining aspirin and acetaminophen is generally considered acceptable, but aspirin should be used cautiously due to stomach irritation and bleeding risk. Patients should avoid alcohol and disclose all medications to their healthcare provider. Due to its opioid component, it is a controlled substance with strict prescribing regulations.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy