Acetaminophen / Aspirin / Caffeine / Salicylamide
This combination medication provides multi-action pain relief by pairing two analgesics (acetaminophen and salicylamide) with aspirin and caffeine, which may enhance the effectiveness of the formula. It is commonly used for tension headaches, migraine relief, and general pain such as muscle aches, backaches, and toothaches. The inclusion of caffeine may help counteract drowsiness sometimes caused by pain.
A multi-ingredient pain reliever combining acetaminophen, aspirin, caffeine, and salicylamide for tension headaches and general pain relief.
Key facts at a glance
- RxNorm
- 689554
- Generic
- Acetaminophen / Aspirin / Caffeine / Salicylamide
- Class
- multi-ingredient
- Brands
- Exaprin, Saleto
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves minor to moderate pain from tension headaches, migraines, muscle aches, backaches, menstrual cramps, toothaches, and fever associated with colds or flu.
Acetaminophen and salicylamide work to reduce pain signals and fever, while aspirin provides anti-inflammatory benefits. Caffeine acts as a mild stimulant that may enhance analgesic effects and improve alertness.
Should not be used in children or teenagers recovering from viral infections due to Reye's syndrome risk (aspirin component). Avoid if allergic to salicylates, have liver disease, or take blood thinners. Should not be used with alcohol as it increases liver risk. Do not take with other acetaminophen or aspirin products.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy