Acetaminophen / Aspirin / Codeine
This combination medication combines a non-opioid analgesic (acetaminophen), an NSAID (aspirin), and an opioid analgesic (codeine) to manage moderate to severe pain. The three ingredients work through complementary mechanisms to provide greater pain relief than any single component alone. This combination is typically reserved for acute pain situations when simpler analgesics have proven insufficient.
A triple-analgesic combination used for moderate to severe pain that requires opioid-level relief.
Key facts at a glance
- RxNorm
- 689555
- Generic
- Acetaminophen / Aspirin / Codeine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Management of moderate to severe acute pain including dental procedures, surgical recovery, injuries, and other conditions requiring analgesia beyond what non-opioid medications can provide.
Acetaminophen provides central pain relief and reduces fever; aspirin inhibits cyclooxygenase enzymes to decrease prostaglandin production and inflammation; codeine is metabolized to morphine to binding opioid receptors in the brain and spinal cord, altering pain perception.
Contains an opioid component with potential for dependence; acetaminophen poses hepatotoxicity risk with high doses or alcohol use; aspirin increases bleeding risk and can cause GI irritation; avoid in children recovering from viral infections due to Reye's syndrome risk; not recommended near delivery or in nursing mothers; patients should avoid operating machinery until they know how the medication affects them.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy