Acetaminophen / Aspirin / Diphenhydramine
This combination medication contains three active ingredients that work together to provide relief from pain, fever, and allergy symptoms while also promoting sleep. Acetaminophen and aspirin address pain and reduce fever, while diphenhydramine, an antihistamine, helps relieve allergy symptoms and causes drowsiness. This makes it particularly useful for nighttime symptom relief when sleep is disrupted by cold, flu, or allergy symptoms.
A multi-ingredient medication for pain, fever, and allergy relief with sleep-promoting effects.
Key facts at a glance
- RxNorm
- 1593109
- Generic
- Acetaminophen / Aspirin / Diphenhydramine
- Class
- multi-ingredient
- Brands
- Excedrin PM Triple Action
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
This medication is used to temporarily relieve minor aches and pains, headache, fever, runny nose, sneezing, and sinus pressure associated with the common cold, flu, or allergies. The sleep-inducing properties make it particularly suitable for nighttime relief when symptoms interfere with rest.
Acetaminophen works in the brain to reduce pain signals and fever. Aspirin inhibits enzymes that produce inflammation and pain. Diphenhydramine blocks histamine receptors, reducing allergic symptoms, and crosses the blood-brain barrier to produce sedation.
This medication should not be used by children or teenagers recovering from viral infections due to the aspirin component. Individuals with aspirin allergies, bleeding disorders, or who consume alcohol regularly should consult a healthcare provider before use. Diphenhydramine may cause drowsiness, so activities requiring alertness should be avoided. Do not take with other products containing acetaminophen or aspirin without medical advice.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy