Acetaminophen / Aspirin / Phenylpropanolamine
This combination medication provides relief from cold and flu symptoms by addressing multiple symptoms simultaneously. Acetaminophen and aspirin work as pain relievers and fever reducers, while phenylpropanolamine acts as a decongestant to reduce nasal swelling. This medication is typically used by adults seeking relief from congestion, headache, body aches, and fever associated with upper respiratory infections.
A multi-symptom cold medication combining two pain relievers with a decongestant for temporary relief of congestion, pain, and fever.
Key facts at a glance
- RxNorm
- 689556
- Generic
- Acetaminophen / Aspirin / Phenylpropanolamine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporary relief of nasal congestion, sinus pressure, headache, minor body aches and pains, and fever associated with the common cold, flu, or sinusitis. May also be used for seasonal allergy symptoms affecting the upper respiratory tract.
Acetaminophen and aspirin reduce pain and fever through their effects on prostaglandin synthesis. Phenylpropanolamine is an alpha-adrenergic agonist that constricts blood vessels in the nasal passages and sinuses, reducing swelling and congestion.
This formulation has been withdrawn from OTC availability in several countries due to stroke risk associated with phenylpropanolamine. Should not be used by individuals with hypertension, heart disease, thyroid disorders, or those taking MAO inhibitors. Combining aspirin and acetaminophen increases the risk of adverse effects; patients should consult healthcare providers before use. Not recommended for children or teenagers due to Reye's syndrome risk with aspirin.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy