Acetaminophen / Benzhydrocodone
Acetaminophen/Benzhydrocodone is a combination medication used to treat moderate to moderately severe pain. It combines a non-opioid pain reliever (acetaminophen) with a semi-synthetic opioid analgesic (benzhydrocodone, a prodrug of hydrocodone) to provide pain relief through different mechanisms of action.
A combination opioid/non-opioid pain medication used for moderate to severe pain when other treatments are insufficient.
Key facts at a glance
- RxNorm
- 2001357
- Generic
- Acetaminophen / Benzhydrocodone
- Class
- multi-ingredient
- Brands
- Apadaz
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Management of acute pain severe enough to require opioid treatment when alternative pain options are inadequate. Typically prescribed for short-term use following surgery, injury, or other painful conditions.
Benzhydrocodone is converted to hydrocodone in the body, binding to opioid receptors in the brain and spinal cord to alter pain perception. Acetaminophen inhibits COX enzymes and may affect endocannabinoid system activity, providing additional analgesic and fever-reducing effects.
Contains an opioid component with risk of dependence, addiction, and respiratory depression. Hepatotoxicity risk from acetaminophen, especially with alcohol use or high doses. Must not be combined with other CNS depressants (benzodiazepines, alcohol, sedatives) without explicit medical supervision. Dosage limited due to acetaminophen content to prevent liver damage.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 24, 2026. · Read our editorial policy