Acetaminophen/Buclizine
Acetaminophen/Buclizine is a combination medication that pairs an analgesic-antipyretic with an antihistamine antiemetic. This combination is primarily used to relieve symptoms associated with motion sickness, including nausea, vomiting, dizziness, and headache. The medication provides multi-symptom relief for travel-related discomfort.
Combination medication for motion sickness relief that addresses nausea, vomiting, and associated pain or fever symptoms.
Key facts at a glance
- RxNorm
- 1007227
- Generic
- Acetaminophen / Buclizine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment and prevention of motion sickness symptoms including nausea, vomiting, dizziness, and headache associated with travel. May also be used for general nausea and related discomfort when combined with mild to moderate pain or fever.
Buclizine is an antihistamine that acts on the vestibular system in the inner ear to reduce nausea and vomiting signals, while also providing antiemetic effects. Acetaminophen works as an analgesic and antipyretic to relieve pain and reduce fever that may accompany motion sickness symptoms.
May cause drowsiness; avoid operating machinery or driving until you know how this medication affects you. Do not exceed recommended dosage as acetaminophen can cause liver damage at high doses. Consult a healthcare provider before use if you have liver disease, glaucoma, urinary retention, or are taking other sedating medications. Not recommended during pregnancy without medical advice.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy