Acetaminophen/Butabarbital
Acetaminophen/Butabarbital is a combination medication that pairs a pain reliever and fever reducer with a barbiturate sedative. This medication is primarily prescribed for the management of moderate to severe pain, particularly when anxiety or tension accompanies the pain condition. The butabarbital component also makes it useful for preoperative sedation and procedural comfort.
A combination pain medication with sedative properties used for moderate-to-severe pain management and anxiety relief.
Key facts at a glance
- RxNorm
- 820541
- Generic
- Acetaminophen / Butabarbital
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of moderate to severe pain, particularly when accompanied by anxiety or tension. Also used for preoperative sedation and procedural comfort in certain clinical settings.
Acetaminophen works by inhibiting cyclooxygenase (COX) enzymes in the brain to reduce pain signals and fever. Butabarbital is a barbiturate that binds to GABA-A receptors, enhancing the inhibitory effects of GABA neurotransmitters to produce sedation and anxiolytic effects.
This medication carries a risk of dependence, addiction, and respiratory depression, particularly due to the barbiturate component. It should be avoided in patients with a history of substance abuse, respiratory depression, or certain liver conditions. Alcohol and other CNS depressants should be avoided. Due to the acetaminophen component, caution is needed in patients with liver disease or heavy alcohol use.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy