Acetaminophen/Butalbital
Acetaminophen/Butalbital is a combination medication used to treat tension headaches and occasionally migraine pain. It combines acetaminophen, a pain reliever and fever reducer, with butalbital, a barbiturate that helps relax muscle tension contributing to headache pain. This medication is typically prescribed when over-the-counter options are insufficient for managing moderate to severe tension-type headaches.
A prescription combination analgesic for tension headaches that combines acetaminophen with a muscle-relaxing barbiturate.
Key facts at a glance
- RxNorm
- 214178
- Generic
- Acetaminophen / Butalbital
- Class
- multi-ingredient
- Brands
- Bupap, Marten-Tab, Tencon, Allzital
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of tension-type headaches and occasionally migraine headaches when milder analgesics are ineffective. Typically prescribed for short-term use due to the risk of dependency associated with the butalbital component.
Acetaminophen works by inhibiting prostaglandin synthesis in the central nervous system to reduce pain perception. Butalbital, a barbiturate, enhances the effects of GABA neurotransmitters and helps relieve muscle contraction that contributes to tension headache pain.
Contains a barbiturate with potential for dependence and abuse. Avoid alcohol and other sedatives while taking. Risk of liver toxicity from acetaminophen with excessive dose or prolonged use. May cause drowsiness; avoid driving until you know how it affects you. Not recommended for regular daily use or for treating chronic headache conditions.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy