Acetaminophen/Butalbital/Caffeine
Acetaminophen/Butalbital/Caffeine is a combination medication used primarily for treating tension-type headaches. It combines a pain reliever (acetaminophen), a barbiturate relaxant (butalbital), and a stimulant (caffeine) to address both the pain and underlying muscle tension associated with headaches.
A combination headache medication that combines pain relief, muscle relaxation, and stimulant effects.
Key facts at a glance
- RxNorm
- 214130
- Generic
- Acetaminophen / Butalbital / Caffeine
- Class
- multi-ingredient
- Brands
- Capacet, Vanatol, Fioricet, Esgic, Repan, Zebutal, Vtol
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily used for tension-type headaches and head pain associated with muscle contraction. May also be prescribed for migraine headaches in some cases.
Acetaminophen provides analgesic (pain-relieving) effects, butalbital promotes muscle relaxation and reduces anxiety, and caffeine constricts blood vessels and enhances the absorption of other ingredients for improved headache relief.
Contains a barbiturate (butalbital) with potential for dependence with prolonged use. Should not be used excessively or for extended periods without medical supervision. May cause drowsiness; avoid operating machinery. Not recommended during pregnancy or for patients with certain liver conditions.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy