Acetaminophen/Butalbital/Caffeine/Hydrocodone
This combination medication is used to treat tension headaches and moderate to severe pain. It combines a barbiturate sedative (butalbital), an opioid pain reliever (hydrocodone), a non-opioid pain reliever (acetaminophen), and caffeine to enhance pain relief effects.
A combination analgesic for tension headaches containing an opioid, barbiturate, acetaminophen, and caffeine.
Key facts at a glance
- RxNorm
- 689562
- Generic
- Acetaminophen / Butalbital / Caffeine / Hydrocodone
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily prescribed for tension headaches and moderate to severe pain conditions requiring opioid-level analgesia. Not typically a first-line treatment due to the risk of dependence and medication-overuse headache.
Hydrocodone binds to opioid receptors in the brain to reduce pain perception. Butalbital provides sedative effects and relaxes muscle tension. Acetaminophen reduces pain and fever, while caffeine may constrict cerebral blood vessels and enhance the effects of other ingredients.
Carries significant risks of dependence, addiction, and respiratory depression especially with prolonged use. Should be used short-term only. Avoid alcohol and other CNS depressants. Contains acetaminophen—doses must be monitored to prevent liver damage. Schedule III controlled substance with strict prescribing regulations.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy