Acetaminophen/Caffeine
Acetaminophen/Caffeine is a combination analgesic used to treat tension headaches, migraines, and mild to moderate pain. The caffeine component enhances the pain-relieving effects of acetaminophen and can help constrict dilated blood vessels associated with headaches. This medication is commonly available over-the-counter and is typically used by adults seeking fast-acting relief from headache pain.
A combination pain reliever and stimulant used for headaches and mild pain, where caffeine boosts acetaminophen's effectiveness.
Key facts at a glance
- RxNorm
- 108038
- Generic
- Acetaminophen / Caffeine
- Class
- multi-ingredient
- Brands
- Excedrin Mild Headache, Sed-Max, Panadol Extra, Excedrin Tension Headache, Excedrin Quick Tab
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Relief of tension headaches, migraine headaches, and general mild to moderate pain including headache, toothache, muscle aches, and menstrual cramps. Often used when over-the-counter acetaminophen alone provides insufficient relief.
Acetaminophen works in the central nervous system to reduce pain perception and fever. Caffeine is a mild stimulant that constricts blood vessels in the brain and enhances the analgesic effects of acetaminophen, providing faster and more effective headache relief.
Do not exceed 4,000mg of acetaminophen daily to avoid liver damage. Avoid alcohol as it increases liver risk. Not recommended during pregnancy without medical consultation. Consult a doctor if pain persists beyond 10 days or fever beyond 3 days. May cause insomnia if taken too late in the day.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy