Acetaminophen/Caffeine/Chlorpheniramine/Guaifenesin/N-Methylephedrine
This is a multi-symptom cold and flu medication combining five active ingredients to address fever, pain, nasal congestion, sneezing, runny nose, and chest congestion. The combination includes an analgesic-antipyretic (acetaminophen), a stimulant (caffeine), an antihistamine (chlorpheniramine), an expectorant (guaifenesin), and a decongestant-bronchodilator (N-methylephedrine). It is typically used by adults experiencing multiple cold or flu symptoms who need relief from both respiratory and systemic symptoms.
A combination cold and flu medication that relieves fever, pain, congestion, sneezing, and chest congestion through five complementary ingredients.
Key facts at a glance
- RxNorm
- 1366507
- Generic
- Acetaminophen / Caffeine / Chlorpheniramine / Guaifenesin / N-Methylephedrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporary relief of common cold and flu symptoms including fever, headache, body aches, nasal congestion, sinus congestion, sneezing, runny nose, itchy throat, and chest congestion. May also be used for allergic rhinitis symptoms.
Acetaminophen reduces fever and pain; caffeine enhances analgesic effects and reduces drowsiness; chlorpheniramine blocks histamine to relieve allergic symptoms; guaifenesin loosens and thins mucus in the airways; N-methylephedrine constricts blood vessels to reduce nasal swelling and opens airways.
Avoid use with alcohol, sedatives, or other acetaminophen-containing products to prevent liver damage. May cause drowsiness; do not drive until you know how it affects you. Consult a doctor before use if pregnant, breastfeeding, or taking other medications. Not recommended for children unless specifically prescribed.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy