Acetaminophen/Caffeine/Chlorpheniramine/Hydrocodone/Phenylephrine
This combination medication contains five active ingredients that work together to provide multi-symptom relief from cold, flu, and allergy symptoms. It addresses pain, fever, nasal congestion, runny nose, sneezing, and cough through complementary mechanisms of action. This medication is typically prescribed when patients need relief from multiple severe symptoms that require an opioid-based analgesic.
A multi-symptom cold/flu medication combining a pain reliever, opioid cough suppressant, antihistamine, decongestant, and stimulant for comprehensive symptom management.
Key facts at a glance
- RxNorm
- 1008298
- Generic
- Acetaminophen / Caffeine / Chlorpheniramine / Hydrocodone / Phenylephrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporary relief of multiple symptoms including headache, body aches, minor pain, fever, nasal congestion, sinus congestion, runny nose, sneezing, itchy/watery eyes, and cough associated with the common cold, flu, or allergies.
Acetaminophen reduces pain and fever; Hydrocodone suppresses cough by acting on the brain's cough center; Chlorpheniramine blocks histamine to relieve allergic symptoms; Phenylephrine constricts blood vessels in nasal passages to reduce congestion; Caffeine enhances the analgesic effects and acts as a stimulant to counteract drowsiness.
Contains an opioid (hydrocodone) with risk of dependence, addiction, and serious breathing problems. Should not be used with alcohol, sedatives, or other CNS depressants. Avoid operating machinery until knowing how medication affects you. Not recommended during pregnancy, breastfeeding, or for children. Contains acetaminophen—exceeding maximum dose may cause liver damage. Consult healthcare provider before use if taking other medications or having underlying health conditions.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy