Acetaminophen/Caffeine/Chlorpheniramine/Phenylephrine
This combination medication provides multi-symptom relief for cold, flu, and allergy symptoms. Acetaminophen reduces fever and pain while caffeine enhances the analgesic effect, chlorpheniramine addresses allergic symptoms like sneezing and runny nose, and phenylephrine relieves nasal congestion.
A multi-symptom cold, flu, and allergy relief medication combining a pain reliever/fever reducer, antihistamine, and decongestant.
Key facts at a glance
- RxNorm
- 819910
- Generic
- Acetaminophen / Caffeine / Chlorpheniramine / Phenylephrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treats common cold, flu, and allergy symptoms including fever, headache, minor body aches, nasal congestion, runny nose, sneezing, and itchy/watery eyes.
Acetaminophen inhibits pain signals and reduces fever; caffeine enhances acetaminophen's effects and reduces drowsiness; chlorpheniramine blocks histamine to relieve allergic reactions; phenylephrine constricts blood vessels in nasal passages to reduce swelling and congestion.
Avoid exceeding the maximum daily dose of acetaminophen to prevent liver damage; caffeine may cause nervousness or sleep disturbances; decongestant effects may increase blood pressure; consult a healthcare provider before use if pregnant, nursing, or taking other medications.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy