Acetaminophen/Caffeine/Chlorpheniramine/Phenylephrine/Pyrilamine
This multi-ingredient medication is used to temporarily relieve symptoms associated with colds, allergies, and sinus congestion. It combines a pain reliever/fever reducer with antihistamines, a decongestant, and caffeine to address multiple symptoms including headache, body aches, nasal congestion, runny nose, sneezing, and sinus pressure.
A combination cold/allergy medication that treats pain, fever, congestion, and allergic symptoms.
Key facts at a glance
- RxNorm
- 689566
- Generic
- Acetaminophen / Caffeine / Chlorpheniramine / Phenylephrine / Pyrilamine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves common cold symptoms, allergic rhinitis, hay fever, and sinus congestion including headache, minor aches and pains, fever, nasal congestion, sneezing, runny nose, itchy/watery eyes, and sinus pressure.
Acetaminophen reduces pain and fever; chlorpheniramine and pyrilamine are antihistamines that block allergic symptoms like sneezing and runny nose; phenylephrine shrinks nasal passages to relieve congestion; caffeine acts as a mild stimulant to counteract drowsiness.
May cause drowsiness; avoid alcohol and operating machinery. Do not use with other products containing acetaminophen. Consult a healthcare provider if you have high blood pressure, heart disease, thyroid problems, diabetes, glaucoma, or prostate issues. Not recommended during pregnancy without medical advice.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy