Acetaminophen/Caffeine/Codeine
Acetaminophen/Caffeine/Codeine is a combination analgesic medication used to treat moderate to severe pain. Acetaminophen and caffeine work together to enhance pain relief, while codeine provides additional opioid-based analgesia for more stubborn pain symptoms. This medication is typically prescribed when over-the-counter pain relievers alone prove insufficient.
A combination pain medication containing an opioid (codeine) used for moderate to severe pain when other analgesics are ineffective.
Key facts at a glance
- RxNorm
- 814657
- Generic
- Acetaminophen / Caffeine / Codeine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used for the relief of moderate to moderately severe pain, including headaches, dental pain, muscle aches, menstrual cramps, and pain following surgical procedures. Often prescribed when single-ingredient or non-opioid analgesics do not provide adequate relief.
Acetaminophen reduces pain perception and fever through central nervous system action. Caffeine enhances the analgesic effects of other ingredients and may help constrict dilated blood vessels associated with headaches. Codeine is an opioid that binds to specific receptors in the brain to alter the perception of pain and produce calming effects.
Contains codeine, an opioid with risk of dependence, tolerance, and respiratory depression. Not recommended for children under 12, adolescents after certain surgeries, or those with respiratory conditions. Avoid alcohol and other CNS depressants. Do not exceed recommended doses due to risk of liver damage from acetaminophen. Should only be used under healthcare provider supervision.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy