Acetaminophen/Caffeine/Codeine/Meprobamate
This combination medication contains four active ingredients that work together to address pain through different mechanisms. Acetaminophen provides pain relief and fever reduction, caffeine enhances analgesic effectiveness, codeine is an opioid for moderate to severe pain, and meprobamate acts as a muscle relaxant to reduce tension that may contribute to pain. This medication is typically prescribed when simpler pain treatments have proven inadequate, often for conditions involving muscle tension such as tension headaches or musculoskeletal pain.
A multi-ingredient pain medication combining an opioid, muscle relaxant, and analgesics for moderate to severe pain with a muscle tension component.
Key facts at a glance
- RxNorm
- 817430
- Generic
- Acetaminophen / Caffeine / Codeine / Meprobamate
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used for the relief of moderate to moderately severe pain, particularly when accompanied by muscle tension or anxiety. Commonly prescribed for tension headaches, musculoskeletal pain conditions, and post-surgical pain when simpler analgesics are insufficient.
Each component works through different mechanisms: acetaminophen inhibits pain signals in the central nervous system, caffeine constricts blood vessels and enhances analgesic effects, codeine binds to opioid receptors to reduce pain perception, and meprobamate acts on GABA receptors to promote muscle relaxation and reduce anxiety-related muscle tension.
This medication contains an opioid (codeine) and carries risks of dependence, tolerance, and respiratory depression. Due to acetaminophen content, liver toxicity is a concern with excessive use or alcohol consumption. Meprobamate also has dependence potential. It should not be combined with alcohol, sedatives, or other CNS depressants. This is a prescription-only medication requiring careful medical supervision and is not appropriate for acute intermittent pain or long-term use without close monitoring.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy