Acetaminophen/Caffeine/Codeine/Salicylamide
This multi-ingredient medication combines four agents for pain relief: acetaminophen and salicylamide provide analgesic and fever-reducing effects, caffeine enhances the effectiveness of other ingredients, and codeine offers opioid-based pain control. It is typically prescribed for moderate to severe pain conditions when other over-the-counter pain relievers are insufficient.
A combination analgesic for moderate to severe pain containing two non-opioid pain relievers, a stimulant, and a mild opioid.
Key facts at a glance
- RxNorm
- 689568
- Generic
- Acetaminophen / Caffeine / Codeine / Salicylamide
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of moderate to severe pain including tension headaches, migraines, dental pain, muscle aches, and pain following surgical procedures. Often used when simpler analgesics have proven ineffective.
This combination works through multiple pathways: acetaminophen and salicylamide inhibit pain signals and reduce fever, caffeine constricts blood vessels and enhances the absorption/effectiveness of other pain relievers, and codeine binds to opioid receptors in the brain to decrease the perception of pain.
Contains codeine, an opioid that carries risks of dependence, tolerance, drowsiness, and respiratory depression. Should not be used by those with respiratory depression, liver impairment, or history of substance abuse. May interact with other CNS depressants. Use the lowest effective dose for the shortest duration. Always follow prescribing physician's instructions carefully.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy