Acetaminophen/Caffeine/Dihydrocodeine
This medication combines three active ingredients to manage moderate to severe pain requiring opioid-level analgesia. Acetaminophen and caffeine enhance pain relief through complementary mechanisms, while dihydrocodeine provides additional analgesic effects through opioid receptor activity. This combination is typically reserved for situations where non-opioid pain relievers prove insufficient.
A combination analgesic containing an opioid (dihydrocodeine), acetaminophen, and caffeine used for moderate to severe pain.
Key facts at a glance
- RxNorm
- 689569
- Generic
- Acetaminophen / Caffeine / Dihydrocodeine
- Class
- multi-ingredient
- Brands
- Trezix
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Management of moderate to severe pain when other analgesics are inadequate, such as pain following surgery, trauma, dental procedures, or other conditions requiring combined opioid and non-opioid analgesia.
Acetaminophen reduces pain perception and fever in the brain; caffeine enhances acetaminophen's analgesic effects and provides mild vasoconstriction useful for certain headache types; dihydrocodeine binds to opioid receptors in the central nervous system to alter pain signal transmission.
Contains an opioid with risk of dependence, tolerance, respiratory depression, and addiction. Use caution in patients with liver impairment (acetaminophen component), respiratory depression risk, or history of substance use disorder. Avoid alcohol and CNS depressants. Monitor for overdose signs, particularly from acetaminophen hepatotoxicity.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy