Acetaminophen/Caffeine/Guaifenesin/Phenylephrine
This combination medication provides multi-symptom relief for cold, flu, and sinus conditions. It addresses pain, fever, congestion, mucus, and fatigue through four complementary ingredients. This product is designed for adults and children seeking comprehensive relief from multiple respiratory symptoms.
A multi-symptom cold and flu remedy combining a pain reliever, stimulant, expectorant, and decongestant.
Key facts at a glance
- RxNorm
- 689570
- Generic
- Acetaminophen / Caffeine / Guaifenesin / Phenylephrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves symptoms associated with the common cold, flu, sinusitis, and allergies including headache, fever, minor aches, nasal congestion, sinus pressure, chest congestion, and mucus buildup.
Acetaminophen reduces pain and fever; Caffeine acts as a stimulant to combat fatigue; Guaifenesin thins and loosens mucus in the airways to make coughs more productive; Phenylephrine shrinks blood vessels in the nasal passages to relieve congestion.
Do not exceed recommended dosage; avoid combining with other acetaminophen-containing products to prevent liver damage; consult a doctor before use if you have heart disease, high blood pressure, thyroid problems, diabetes, or prostate issues; do not use if you are taking MAOI inhibitors or have used them within the past 14 days.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy