Acetaminophen/Caffeine/Homatropine
Acetaminophen/Caffeine/Homatropine is a combination medication used primarily for tension headaches and mild to moderate pain. Acetaminophen provides pain relief and fever reduction, caffeine enhances the effectiveness of pain medications and may help constrict dilated blood vessels, and homatropine acts as an antispasmodic to help relax muscles. This combination targets both the pain and muscle tension components often associated with tension-type headaches.
A combination analgesic used for tension headaches that addresses pain, muscle tension, and includes a stimulant to enhance pain relief.
Key facts at a glance
- RxNorm
- 1007965
- Generic
- Acetaminophen / Caffeine / Homatropine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of tension headaches, mild to moderate pain, and sometimes migraine-associated symptoms. May also be used for headache pain associated with sinus pressure or muscle tension.
Acetaminophen inhibits pain signals in the central nervous system; caffeine acts as a mild stimulant that enhances analgesic effects and may reduce headache pain through vasoconstriction; homatropine provides antispasmodic effects to help relax tense muscles in the head and neck region.
Due to caffeine content, avoid taking close to bedtime to prevent sleep disturbance. Do not exceed recommended daily dose of acetaminophen to avoid liver damage. Consult a healthcare provider before use if pregnant, breastfeeding, or taking other medications. Not recommended for prolonged daily use without medical supervision.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy